Rome Season 1 2005 Bluray 1080p Dts X264-chd

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Rome Season 1 2005 Bluray 1080p Dts X264-chd



 


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Today, the Roman Empire is one of the most powerful.High-dose zinc supplementation affects cytokine production and the microbiota composition in young pigs. Zinc is a key trace element, which plays a vital role in the proper development and functioning of the immune system. The optimal intake of zinc has been extensively studied in experimental animals but not in humans. We investigated the effect of high-dose zinc supplementation in young pigs on the immune system and the gut microbiota composition. Forty pigs of the landrace Aweida pig were assigned to two groups: zinc supplemented group and control group. The experimental group was supplemented with zinc by feeding it at the rate of 0.6% of the diet and the control group was fed the basal diet. The experiment lasted for 21 days and blood samples were collected to measure serum zinc concentrations. The fecal microbiota composition was analyzed by denaturing gradient gel electrophoresis (DGGE). The results showed that the serum zinc concentration was significantly higher in the zinc supplemented group. The supplementation also resulted in an increase in the levels of several cytokines including IL-1β, IL-6 and TNF-α and the expression of immunoregulatory enzymes (TSLP, CXCL8, TLR3 and TLR7) in the blood. Significant changes were also observed in the microbiota composition. Supplementation with high-dose zinc increases the serum zinc concentration and modifies the composition of the microbiota. These changes were associated with the increased expression of immunoregulatory genes and the production of cytokines. Therefore, high-dose zinc supplementation can modulate the immune system and improve the gut microbiota in young pigs.The goals of this project are to discover the role of T cell derived cytokines in the pathogenesis of autoimmune disorders, such as type I diabetes (IDDM), and to develop approaches for blocking cytokine function as a treatment for autoimmune diseases. A major focus of this proposal is to identify the molecular and cellular basis for the anti-inflammatory effects of IL-10 and TGF-beta on T cell function. IL-10 and TGF-beta have been demonstrated to inhibit lymphokine production by activated T cells and to prevent the development of IDDM in the NOD mouse model of the disease. IL-10 was shown to inhibit cytokine production and cytotoxicity by diabetogenic T cells from NOD mice. A correlation was found between diabetogenicity and the production of IL-2 and IFN-gamma by such cells. IL

 

 


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